UK Biobank Cohort - DPUK Data Portal

Cohort Descriptives

Variable	Response
Cohort Name	UK Biobank
Cohort Acronym	UK Biobank
DOI	Collins, R. (2017). UK Biobank [Data set]. Dementias Platform UK. https://doi.org/10.48532/046000
Study Overview	UK Biobank aims to assess the relevance of a very wide range of health-related outcomes. It is a large prospective study to investigate the role of genetic factors, environmental exposures and lifestyle in the causes of major diseases of late and middle age. During 2006-2010, UK Biobank conducted its recruitment phase of more than 500,000 participants who gave their consent, answered questions, had physical measurements and gave samples (blood, urine and saliva) at a Baseline assessment visit. Follow-up of their health is now being conducted through medical and other health-related records. Access systems have been developed to facilitate use of the UK Biobank Resource by bona fide researchers for health-related research that is in the public interest.
#Subjects at Baseline	503316
Institution Name	UK Biobank
Department Name	UK Biobank Coordinating Centre
City	Stockport
Study/Database Website	https://www.ukbiobank.ac.uk
Principal Investigator (PI)	Professor Sir Rory Collins
Key Study References	Please see literature section
Population Based Study?	Yes
Family Based Study?	No
Clinical based sample?	No
Is there follow-up data available?	Yes
Were participants included prior to development of dementia (may refer to controls only)?	Yes
Were participants included prior to development of MCI (may refer to controls only)?	Yes
How is data collected?	A combination of in person, postal and internet
Who carries out data collection?	Interviewers and clinical staff: Key staff are research nursing and technical staff
Does this take place in participants' homes or at a central location?	Home and Central: Baseline visit at central location (office space). Pedometry (100,000) and email questionnaires (300,000) sent to participants and carried out at home. There are additional web based questionnaires that will also be carried out at home.
Do participants take part individually or are families/partners involved?	Individually
Dementia cases ascertained as part of study:	No
How many times followed up?	2, with online questionnaires at intervals
How regular is follow-up?	Subgroups followed up more frequently, with online questionnaires asking about diet, work history, patricipants' thoughts and feelings and cognitive function.
# Subjects at Follow-up	20,000 at repeat assessment, aim of 100,000 at imaging visit
Study start date	01/01/2006 00:00:00
Is study ongoing?	Yes
Is study still recruiting?	No
Inclusion criteria	Age 40-69 years at recruitment. Capacity to consent. Lived within 20-25 miles of one of the assessment centres.
Exclusion criteria	UK Biobank did not enrol potential participants who express the view that they would want to be withdrawn should they lose mental capacity or die because this would reduce the value of the resource for research.

Administration

Variable type
Age at recruitment
Assessment centre
Date of birth
Date of consenting to join UK Biobank
Email access
Home location at assessment
ID
Reason/date lost to follow-up
Sex

Sociodemographic

Sub-category	Variable type	Baseline	1	2	Online Follow-up
Deprivation	Able to pay rent/mortgage as an adult				Y
Deprivation	Accommodation	Y	Y	Y
Deprivation	Household information	Y	Y	Y
Deprivation	Townsend deprivation index at recruitment	Y
Education	Age completed full time education	Y	Y	Y
Education	Qualifications	Y	Y	Y
Education	Year ended full time education				Y
Employment	Attendance/disability/mobility allowance	Y	Y	Y
Employment	Current employment status	Y
Employment	Current/main job information	Y	Y	Y
Employment	Distance between home and job workplace	Y	Y	Y
Employment	Job information				Y
Ethnicity	Ethnic background	Y
Ethnicity	Year immigrated to UK	Y	Y	Y

Family History

Sub-category	Variable type	Baseline	1	2
Extended	Non-accidental death in close genetic family	Y	Y	Y
Father	Father (natural and adopted)	Y	Y	Y
Mother	Mother (natual and adopted)	Y	Y	Y
Siblings	Siblings (natual and adopted)	Y	Y	Y

Early Life History

Sub-category	Variable type	Baseline	1	2	Online Follow-up
Birth	Adopted as a child	Y	Y	Y
Birth	Birth weight	Y	Y	Y
Birth	Born by caesarian section				Y
Birthplace	Country of birth (non-UK)	Y
Birthplace	Place of birth (UK)	Y	Y	Y
Body Size Child	Comparative body/height size at age 10	Y	Y	Y
Breastfed	Breastfed as a baby	Y	Y	Y
Childhood Environment	Long-term antibiotics as a child				Y
Handedness	Handedness (chirality/laterality)	Y	Y	Y
Mother Smoked	Maternal smoking around birth	Y	Y	Y
Twin Birth	Part of a multiple birth	Y	Y	Y

Physical Health Status

Sub-category	Variable type	Baseline	1	2	Online Follow-up
Cancer	Cancer	Y	Y	Y
Cancer	Cancer screenings	Y	Y	Y
Cancer	Lung cancer				Y
Cancer	Self-reported cancers/non-cancer illnesses	Y	Y	Y
Cardiothoracic	Heart attack	Y	Y	Y
Cardiothoracic	Myocardial infarction			Y
Cardiothoracic	STEMI/NSTEMI			Y
Cardiothoracic	Various cardiothoracic conditions	Y	Y	Y
Cardiothoracic	Vascular/heart problems	Y	Y	Y
Cerebrovascular	Intracerebral/subarachnoid haemorrhage			Y
Cerebrovascular	Ischaemic stroke			Y
ENT	Frequency of loud music exposure	Y	Y	Y
ENT	Mouth/teeth dental problems	Y	Y	Y
ENT	Tinnitus severity/nuisance	Y	Y	Y
Eyes	Current eye infection	Y	Y
Eyes	Eye problems/disorders	Y	Y	Y
Eyes	Glasses/contact lenses	Y	Y	Y
Eyes	Glaucoma/cataract diagnosed	Y	Y	Y
Eyes	Which eye(s) affected by various eye conditions	Y	Y	Y
Gastrointestinal	Abdominal pain/discomfort				Y
Gastrointestinal	Coeliac disease/gluten sensitivity				Y
Gastrointestinal	General gastro-intestinal health				Y
Gastrointestinal	Irritable Bowel Syndrome (IBS)				Y
General Health	Diabetes/gestational diabetes	Y	Y	Y
General Health	Falls and resulting fractures	Y	Y	Y
General Health	Long-standing illness, disability or infirmity	Y	Y	Y
General Health	Other serious medical condition/disability	Y	Y	Y
General Health	Overall health rating	Y	Y	Y
General Health	Weight change compared with 1 year ago	Y	Y	Y
Immunological	Hay fever/rhinitis/eczema	Y	Y	Y
Pain	Body/joint/general pain report	Y	Y	Y
Respiratory	Various lung diseases/illnesses				Y
Respiratory	Wheeze or whistling in the chest/shortness of breath	Y	Y	Y

Reproductive History

Sub-category	Variable type	Baseline	1	2
Female	Age at first/last live birth	Y	Y	Y
Female	Age of primiparous women at birth of child	Y	Y	Y
Female	Age when periods started	Y	Y	Y
Female	Birth weight of first child	Y	Y	Y
Female	Hormone-replacement therapy (HRT)	Y	Y	Y
Female	Hysterectomy/oophorectomy (both ovaries removed)	Y	Y	Y
Female	Menopause	Y	Y	Y
Female	Menstrual cycles	Y	Y	Y
Female	Number of live births	Y	Y	Y
Female	Oral contraceptive pill	Y	Y	Y
Female	Stillbirth/spontaneous miscarriage/termination	Y	Y	Y
Male	Hair/balding pattern	Y	Y	Y
Male	Number of children fathered	Y	Y	Y
Male	Relative age of first facial hair	Y	Y	Y
Male	Relative age voice broke	Y	Y	Y

Healthcare Utilisation

Sub-category	Variable type	Baseline	1	2	Online Follow-up
Health Insurance	Private healthcare	Y	Y	Y
Medications	Treatments/medications for various illnesses				Y
Medications	Vitamin, mineral and other dietary supplements	Y	Y	Y
Surgery	Ever had eye surgery	Y	Y
Surgery	Major operations	Y	Y	Y
Surgery	Pace-maker	Y	Y	Y
Surgery	Surgery/amputation of toe or leg	Y	Y	Y

Life Functionality

Sub-category	Variable type	Baseline	1	2	Online Follow-up
Assistive devices	Hearing aid/cochlear implant	Y	Y	Y

Psychological Status

Sub-category	Variable type	Baseline	1	2	Online Follow-up
Personality	Neuroticism score			Y
Personality	Risk taking	Y	Y	Y
Personality	Suffer from 'nerves'	Y	Y	Y
Personality	Tense/'highly strung'	Y	Y	Y
Sleep	Extensive sleep assessment	Y	Y	Y
Wellbeing	Belief that own life is meaningful				Y
Wellbeing	General happiness/satisfaction assessment				Y

Mental Health Status

Sub-category	Variable type	Baseline	1	2	Online Follow-up
Abuse	Belittlement by partner or ex-partner as an adult				Y
Abuse	Felt hated/physically abused by family member as a child				Y
Abuse	Felt loved as a child				Y
Abuse	Physical violence/sexual interference by partner without consent as an adult				Y
Abuse	Someone to take to doctor when needed as a child				Y
Abuse	Victim of sexual assault as a child/adult				Y
Addictions	Addiction to any substance/behaviour/alcohol/miscellaneous				Y
Addictions	Addiction to illicit or recreational drugs/over-the-counter medication				Y
Consultation	Ever sought or received professional help for mental distress				Y
Consultation	Ever talked to a health professional about unusual or psychotic experiences				Y
Disorders	Bipolar disorder			Y
Mood	Been in a confiding relationship as an adult				Y
Mood	Depression/anxiety				Y
Mood	Mania/irritability/anger				Y
Mood	Mental health questionnaire				Y
Mood	Mood/feelings assessment	Y	Y	Y
Mood	Psychotic experiences				Y
Mood	Stress				Y
Mood	Unenthusiasm/disinterest	Y	Y	Y
Self Harm	Self-harm				Y
Self Harm	Suicide				Y
Trauma	Diagnosed with life-threatening illness				Y
Trauma	Traumatic experience (serious accident, combat/war-zone, violent crime/death)				Y

Cognition

Sub-category	Variable type	Baseline	1	2	Online Follow-up
Cognitive Performance	Aide-memoire completed	Y	Y
Cognitive Performance	Fluid intelligence				Y
Cognitive Performance	Number/history of attempts	Y	Y	Y
Cognitive Performance	Numeric memory				Y
Cognitive Performance	Pairs matching				Y
Cognitive Performance	Symbol digit substitution				Y
Cognitive Performance	Trail making				Y
Cognitive Performance	Willing to attempt cognitive tests	Y	Y	Y
Cognitive Status	Alzheimer's disease			Y
Cognitive Status	Dementia			Y
Cognitive Status	Frontotemporal dementia			Y
Cognitive Status	Parkinson's disease			Y
Cognitive Status	Vascular dementia			Y

Lifestyle

Sub-category	Variable type	Baseline	1	2	Online Follow-up
Alcohol	Alcohol drinker status	Y	Y	Y
Alcohol	Alcohol intake versus 10 years previously	Y	Y	Y
Alcohol	Alcohol usually taken with meals	Y	Y	Y
Alcohol	Average weekly/monthly alcohol intake	Y	Y	Y
Alcohol	Former alcohol drinker/reason stopped drinking alcohol	Y	Y	Y
Alcohol	Size of wine glass drunk	Y			Y
Diet	Carbohydrate intake	Y			Y
Diet	Dairy intake	Y			Y
Diet	Extensive diet questionnaires completed	Y			Y
Diet	Fat intake	Y			Y
Diet	Fruit/vegetable intake	Y			Y
Diet	Hot drink intake	Y			Y
Diet	Meat/fish/vegetarian alternative intake	Y			Y
Diet	Other drink intake	Y			Y
Diet	Portion size/typical diet	Y			Y
Diet	Salt added to food	Y	Y	Y	Y
Diet	Savoury/sweet snack intake	Y			Y
Diet	Spreads/sauces intake	Y			Y
Diet	Total sugars	Y			Y
Diet	Type of special diet followed	Y			Y
Diet	Vitamins/minerals	Y			Y
Digital Technology	Difference in mobile phone use compared to two years previously	Y	Y	Y
Digital Technology	Hands-free device/speakerphone use in last 3 months	Y	Y	Y
Digital Technology	Mobile phone use	Y	Y	Y
Digital Technology	Plays computer games	Y	Y	Y
Digital Technology	Time spent watching TV/using computer	Y	Y	Y
Digital Technology	Usual side of head for mobile phone use	Y	Y	Y
Leisure	Leisure/social activities	Y	Y	Y
Physical	Moderate/vigorous activity	Y	Y	Y
Physical	Other activity/exercise	Y	Y	Y
Physical	Time spent doing physical activity	Y			Y
Physical	Walking	Y	Y	Y
Sexual	Sexual history	Y	Y	Y
Smoking	Smoking history	Y	Y	Y
Substances	History of alcohol/substances intake				Y
Travel	Driving/other transport	Y	Y	Y

Physical Environment

Sub-category	Variable type	Baseline	1	2	Online Follow-up
Housing	Date first recorded at location			Y
Housing	Home location & area population density			Y
Sun Exposure	Facial ageing	Y	Y	Y
Sun Exposure	Frequency of solarium/sunlamp use	Y	Y	Y
Sun Exposure	Hair colour (natural, before greying)	Y	Y	Y
Sun Exposure	Skin colour/ease of tanning/sunburn occasions	Y	Y	Y
Sun Exposure	Time spent outdoors in summer/winter	Y	Y	Y
Sun Exposure	Use of sun/uv protection	Y	Y	Y
Work	Breathing problems/frequent cough due to workplace/job				Y
Work	Devices used at work				Y
Work	Gap periods				Y
Work	Noisy workplace	Y	Y	Y
Work	Shift work (day/night)				Y
Work	Tobacco smoking in the work place				Y
Work	Transport to workplace	Y	Y	Y
Work	Work hours				Y
Work	Workplace conditions				Y

Social Environment

Sub-category	Variable type	Baseline	1	2
Life Events	Illness, injury, bereavement, stress in last 2 years	Y	Y	Y
Social Interaction	Able to confide	Y	Y	Y
Social Interaction	Frequency of friend/family visits	Y	Y	Y

Physical Examination

Sub-category	Variable type	Baseline	1	2
Accelerometer	Acceleration average/standard deviation			Y
Accelerometer	Accelerometer administrative data			Y
Accelerometer	Calibration of data			Y
Accelerometer	Data recording errors			Y
Accelerometer	Fraction acceleration			Y
Accelerometer	Wear duration during each day/hour of the week			Y
Anthropometry	Body mass index (BMI)	Y	Y
Anthropometry	Height (standing, seated)	Y	Y	Y
Anthropometry	Impedance of limbs, whole body	Y	Y	Y
Anthropometry	Waist/hip circumference	Y	Y	Y
Anthropometry	Weight	Y	Y	Y
Anthropometry	Whole body fat mass/percentage	Y	Y
Anthropometry	Whole body water mass	Y	Y
Ear	Extensive hearing assessments	Y	Y	Y
Eye	Extensive eye/sight assessments	Y	Y
Heart	Cardiac assessments	Y	Y	Y
Heart	ECG assessments	Y	Y
Lung	Caffeine drank within last hour	Y	Y	Y
Lung	Extensive lung assessments	Y	Y	Y
Lung	Smoked cigarette or pipe within last hour	Y	Y	Y
Lung	Used an inhaler for chest within last hour	Y	Y	Y
Metabolism	Basal metabolic rate	Y	Y
Strength	Hand grip strength	Y	Y	Y

Linkage Data

Sub-category	Variable type	1	2
Cancer Register	Cancer diagnosis	Y
Death Register	Date of/age at death	Y
HES	Administrative and legal statuses	Y
HES	Admissions/discharges from hospital	Y
HES	Diagnoses	Y
HES	External causes	Y
HES	Inpatient record format		Y
HES	Intended management of patient	Y
HES	Main/treatment speciality of consultant	Y
HES	Operative procedures	Y	Y
HES	Patient classification on admission	Y
HES	PCT where patients GP was registered	Y
HES	Spell and episode data	Y

Biosample Assays

Sub-category	Variable type	Baseline	1	2
Biochemistry	Saliva samples	Y	Y
Biochemistry	Urine samples	Y	Y
Haematology	Analyses of blood components	Y	Y	Y
Haematology	Analyses of various types of red blood cell	Y	Y	Y
Haematology	Analyses of various types of white blood cell	Y	Y	Y
Haematology	Blood cell counts (red/white)	Y	Y	Y
Haematology	Blood samples	Y	Y	Y
Haematology	Haemoglobin concentration/percentage	Y	Y	Y
Haematology	Mean corpuscular volume/haemoglobin	Y	Y	Y
Haematology	Mean sphered cell volume tests	Y	Y	Y
Haematology	Platelet analyses	Y	Y	Y

Imaging

Sub-category	Variable type	Baseline	1	2
BMD	Android measurements			Y
BMD	DXA scans			Y
BMD	L1-L4 measurements			Y
BMD	Various body part measurements	Y	Y	Y
BMD	VAT (visceral adipose tissue) mass & volume			Y
MRI	Abdominal MRI			Y
MRI	Brain MRI			Y
MRI	Cardiac MRI			Y
MRI	FA skeleton MRI			Y
MRI	rfMRI (resting-state functional MRI)			Y
MRI	T1/T2 MRI			Y
MRI	tfMRI (task-based functional MRI)			Y

Genomics

Sub-category	Variable type	2
Genotyping	Chromosome genotype probabilities/intensities	Y
Genotyping	DNA concentration	Y
Genotyping	Extensive genotyping	Y
Genotyping	Genetic ethnic grouping	Y
Genotyping	Genetic kinship to other participants	Y
Genotyping	Genetic principal components	Y
Genotyping	Genetic relatedness	Y
Genotyping	Genetic sex	Y
Genotyping	Genotype measurement batch/plate/well	Y
Genotyping	Mitochondrial genotype probabilities/intensities	Y
Genotyping	Recommended genomic analysis exclusions	Y
Genotyping	UKBiLEVE Affymetrix/genotype quality control for samples	Y
Genotyping	UKBiLEVE unrelatedness indicator	Y

Built Environment

Sub-category	Variable type	Baseline	1	2
Morphometrics	Distance (Euclidean) to coast	Y	Y
Morphometrics	Greenspace/domestic garden percentage	Y	Y
Morphometrics	Natural environment percentage	Y	Y
Morphometrics	Water percentage	Y	Y
Pollution	Average sound level of noise pollution			Y
Pollution	Close to major road			Y
Pollution	Nitrogen oxides air pollution			Y
Pollution	Particulate matter air pollution			Y
Pollution	Sum of road length of major roads within 100m			Y
Pollution	Traffic intensity/loads on nearest roads			Y